The complex pathogenesis of bacteremia
نویسندگان
چکیده
Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are associated with susceptibility to infection. The pathogenesis of bacteremia has some characteristic features that are influenced by the genetic signature of the host. In this review, the host defense mechanisms that help prevent bacteremia will be described and the populations who are at risk because of congenital or acquired deficiencies in such mechanisms will be defined. A special mention will be made to novel insights regarding host immune defense against the most commonly isolated organisms from patients with community-acquired bloodstream infections.
منابع مشابه
Bacteremia
Invasion of the blood stream in the course of bacterial infection is a dramatic biological phenomenon, the clinical recognition of which has both diagnostic and prognostic significance. Despite the difficulties inherent in separating a single phase of the struggle between parasite and host from the complex process of the pathogenesis of infection, the peculiar clinical importance of bacteremia ...
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